O'Shea K S, Kaufman M H
J Neurogenet. 1983 Sep;1(1):29-38. doi: 10.3109/01677068309107070.
Neural tube closure was studied in embryos obtained from matings of male mice heterozygous for a reciprocal chromosome translocation (T(2;4)1 Sn) with normal female (CFLP) mice. When litters were examined on the 9th to 12th days of gestation, there was a high incidence of resorption, developmental delay and neural tube closure defects in these embryos. SEM observations indicated that the neural tube closure defects ranged in severity from a side-to-side flattening of the midbrain to extensive anomalies in which the entire cephalic neural tube had failed to close. In addition to cephalic defects, a number of embryos exhibited open defects or abnormal subectodermal blebbing in the future lumbosacral region. In spinal regions, even in areas in which the neural tube had previously closed, it often was irregular and folded. These observations are discussed in relation to studies of gene-related defects of neural tube closure.
在由雄性杂合 reciprocal 染色体易位（T(2;4)1 Sn）的小鼠与正常雌性（CFLP）小鼠交配所获得的胚胎中研究神经管闭合情况。当在妊娠第9至12天检查窝仔时，这些胚胎中出现吸收、发育延迟和神经管闭合缺陷的发生率很高。扫描电子显微镜观察表明，神经管闭合缺陷的严重程度从大脑中侧向扁平到广泛异常不等，在广泛异常中整个头部神经管未能闭合。除了头部缺陷外，许多胚胎在未来腰骶部区域表现出开放性缺陷或外胚层下异常起泡。在脊髓区域，即使在神经管先前已闭合的区域，其通常也是不规则的且有褶皱。结合与神经管闭合相关基因缺陷的研究对这些观察结果进行了讨论。
