Reeve J
Clin Endocrinol (Oxf). 1978 Jun;8(6):445-55. doi: 10.1111/j.1365-2265.1978.tb02181.x.
(1) A non-compartmental method is described for analysing the kinetics of the exchange of calcium between the bloodstream and the exchangeable bone pools. (2) This method has been applied to studies on osteoporotic patients treated with low doses of an active fragment of human parathyroid hormone. The data of Phang et al. (1969), who studied the effects of dietary calcium peturbation on normal volunteers, were also analysed. (3) It was found that in response to chronic PTH treatment the transit time of calcium in the exchangeable pools decreased. This could not be explained by the observed changes in the calcium accretion rate to the fixed bone pools, and it was necessary to postulate an alteration in the ratio of the rate constants governing the interchange of calcium between bloodstream and exchangeable pools. (4) The changes in the behaviour of the exchangeable pools in response to dietary perturbation could not be explained by the postulated increase in endogenous PTH secretion rate in response to dietary calcium restriction.
(1) 描述了一种非房室方法，用于分析血液与可交换骨池之间钙交换的动力学。(2) 该方法已应用于对接受低剂量人甲状旁腺激素活性片段治疗的骨质疏松患者的研究。还分析了Phang等人（1969年）关于饮食钙扰动对正常志愿者影响的数据。(3) 发现响应慢性甲状旁腺激素治疗，可交换池中钙的转运时间缩短。这无法用观察到的钙向固定骨池的沉积速率变化来解释，因此有必要假定控制血液与可交换池之间钙交换的速率常数比值发生了改变。(4) 饮食扰动引起的可交换池行为变化，无法用假定的饮食钙限制引起内源性甲状旁腺激素分泌速率增加来解释。
