Cumming F J, Briggs M H
Br J Obstet Gynaecol. 1983 Jan;90(1):73-7. doi: 10.1111/j.1471-0528.1983.tb06750.x.
Plasma vitamin A and retinol-binding protein (RBP) concentrations have been studied in women using oral contraceptives (OC) for up to 4 years. In eight women taking an oestrogenic OC(1 mg of norethisterone acetate + 50 micrograms of ethinyloestradiol) values almost doubled within 6 months, but diminished somewhat after 4 years. Saturation of RBP with retinol remained fairly constant. Five lactating women who took progestogen-only OC (30 micrograms of levonorgestrel or 350 micrograms of norethisterone) showed no significant alteration in plasma vitamin A or RBP concentrations as compared with nine lactating non-OC users. All lactating women showed significant differences between the highest and lowest plasma vitamin A (P less than 0.005) and RBP (P less than 0.05) concentrations during the first 6 months of lactation. Highest values occurred 11-12 weeks postpartum and the lowest at 15-17 weeks. Percentage saturation of RBP with retinol was significantly higher (P less than 0.005) when vitamin A concentration was highest.
对使用口服避孕药（OC）长达4年的女性血浆维生素A和视黄醇结合蛋白（RBP）浓度进行了研究。在8名服用含雌激素OC（1毫克醋酸炔诺酮+50微克乙炔雌二醇）的女性中，其数值在6个月内几乎翻倍，但4年后有所下降。视黄醇对RBP的饱和度保持相当稳定。与9名未使用OC的哺乳期女性相比，5名仅服用孕激素OC（30微克左炔诺孕酮或350微克炔诺酮）的哺乳期女性血浆维生素A或RBP浓度无显著变化。所有哺乳期女性在哺乳期的前6个月血浆维生素A最高值与最低值（P<0.005）和RBP（P<0.05）浓度之间均存在显著差异。最高值出现在产后11 - 12周，最低值出现在15 - 17周。当维生素A浓度最高时，视黄醇对RBP的饱和度显著更高（P<0.005）。
