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1
Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease.大唑氧苯对冠心病经心腔血栓素水平及血流动力学的影响。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):79S-82S. doi: 10.1111/j.1365-2125.1983.tb02113.x.
2
Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing.达唑氧苯在静息及心房起搏时的血流动力学和代谢效应。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):73S-77S. doi: 10.1111/j.1365-2125.1983.tb02112.x.
3
Effects of dazoxiben on exercise performance in chronic stable angina.达唑氧苯对慢性稳定型心绞痛运动能力的影响。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):83S-86S. doi: 10.1111/j.1365-2125.1983.tb02114.x.
4
Effect of the thromboxane synthetase inhibitor UK-37,248 (dazoxiben) upon platelet aggregation, coronary artery thrombosis and vascular reactivity.血栓素合成酶抑制剂UK-37,248（达唑氧苯）对血小板聚集、冠状动脉血栓形成及血管反应性的影响。
J Pharmacol Exp Ther. 1983 Dec;227(3):790-6.
5
Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test.特异性血栓素合成酶抑制对运动试验诱发的稳定型心绞痛中血栓素和前列腺素合成的影响。
Thromb Res. 1985 Jan 15;37(2):259-66. doi: 10.1016/0049-3848(85)90014-3.
6
Dazoxiben examined for platelet inhibitory effect in an artificial circulation.对大唑昔本进行人工循环中的血小板抑制作用研究。
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):61S-65S. doi: 10.1111/j.1365-2125.1983.tb02109.x.
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The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism.血栓素合成酶抑制剂达唑氧苯和乙酰水杨酸对血小板功能及前列腺素代谢的影响。
Thromb Haemost. 1983 Oct 31;50(3):703-6.
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Effects of a selective thromboxane synthetase inhibitor, dazoxiben, and of acetylsalicylic acid on myocardial ischemia in patients with coronary artery disease.选择性血栓素合成酶抑制剂达唑氧苯和乙酰水杨酸对冠心病患者心肌缺血的影响。
Am J Cardiol. 1984 May 1;53(9):1255-8. doi: 10.1016/0002-9149(84)90074-2.
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Effects of provocation on transcardiac thromboxane in patients with coronary artery disease.
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10
Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries.选择性血栓素合成酶抑制剂达唑氧苯对犬冠状动脉狭窄时周期性血流变化的影响。
Circulation. 1984 Jun;69(6):1161-70. doi: 10.1161/01.cir.69.6.1161.

引用本文的文献

1
Effect of the specific thromboxane receptor blocking drug AH23848 in patients with angina pectoris.特异性血栓素受体阻断药物AH23848对心绞痛患者的疗效。
Br Heart J. 1986 Dec;56(6):509-17. doi: 10.1136/hrt.56.6.509.

本文引用的文献

1
Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature.起搏诱导型心绞痛期间的血栓素释放：对冠状动脉血管系统可能的血管收缩作用影响。
Circulation. 1980 Jun;61(6):1165-71. doi: 10.1161/01.cir.61.6.1165.
2
Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris.典型和变异型心绞痛患者血栓素B2水平升高。
Circulation. 1981 Dec;64(6):1107-15. doi: 10.1161/01.cir.64.6.1107.
3
Platelet counts and aggregates in coronary artery disease.
Eur Heart J. 1982 Apr;3(2):107-13. doi: 10.1093/oxfordjournals.eurheartj.a061271.
4
Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease.缺血性心脏病患者体内前列腺素和血栓素释放至冠状动脉循环中。
N Engl J Med. 1981 Mar 19;304(12):685-91. doi: 10.1056/NEJM198103193041201.
5
Platelet activation in clinical coronary artery disease and spasm.
Am Heart J. 1981 Sep;102(3 Pt 1):363-7. doi: 10.1016/0002-8703(81)90310-0.
6
Elevated beta thromboglobulin in peripheral venous blood of patients with acute myocardial ischemia: direct evidence for enhanced platelet reactivity in vivo.急性心肌缺血患者外周静脉血中β-血小板球蛋白升高：体内血小板反应性增强的直接证据。
Am J Cardiol. 1981 Sep;48(3):395-402. doi: 10.1016/0002-9149(81)90065-5.
7
Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo.血浆β-血小板球蛋白和血小板第4因子水平作为体内血小板活化指标。
Blood. 1981 Feb;57(2):199-202.
8
Thromboxane synthetase inhibition as antithrombotic strategy.抑制血栓素合成酶作为抗血栓形成策略。
Lancet. 1981 May 16;1(8229):1073-5. doi: 10.1016/s0140-6736(81)92241-8.
9
Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase.给人施用UK-37,248-01，一种血栓素合成酶的选择性抑制剂。
Lancet. 1981 Mar 21;1(8221):629-32. doi: 10.1016/s0140-6736(81)91551-8.
10
Prostacyclin: haemodynamic and metabolic effects in patients with coronary artery disease.前列环素：对冠心病患者的血流动力学及代谢影响
Lancet. 1981 Mar 14;1(8220 Pt 1):569-72. doi: 10.1016/s0140-6736(81)92028-6.

大唑氧苯对冠心病经心腔血栓素水平及血流动力学的影响。

Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease.

作者信息

Hutton I, Tweddel A C, Rankin A C, Walker I D, Davidson J F

出版信息

Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):79S-82S. doi: 10.1111/j.1365-2125.1983.tb02113.x.

DOI:10.1111/j.1365-2125.1983.tb02113.x
PMID:6681709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1427691/
Abstract

1 Plasma thromboxane levels were obtained from both the coronary sinus and aorta in patients with stable angina pectoris paced to angina, and in unstable angina patients before and after dazoxiben 100 mg. 2 Although there was a wide range of values in the different groups, dazoxiben significantly reduced plasma thromboxane levels in all patients. 3 Dazoxiben had no adverse effect on coronary and systemic haemodynamics, and atrial pacing time to angina was increased from 245 +/- 41 to 308 +/- 48s (P less than 0.01).

摘要
  1. 在稳定型心绞痛患者诱发心绞痛时以及不稳定型心绞痛患者服用100毫克达唑氧苯前后，分别从冠状窦和主动脉获取血浆血栓素水平。2. 尽管不同组的值范围较宽，但达唑氧苯显著降低了所有患者的血浆血栓素水平。3. 达唑氧苯对冠状动脉和全身血流动力学无不良影响，心绞痛发作的心房起搏时间从245±41秒增加到308±48秒（P<0.01）。