大唑氧苯对冠心病经心腔血栓素水平及血流动力学的影响。
Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease.
作者信息
Hutton I, Tweddel A C, Rankin A C, Walker I D, Davidson J F
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):79S-82S. doi: 10.1111/j.1365-2125.1983.tb02113.x.
Abstract
1 Plasma thromboxane levels were obtained from both the coronary sinus and aorta in patients with stable angina pectoris paced to angina, and in unstable angina patients before and after dazoxiben 100 mg. 2 Although there was a wide range of values in the different groups, dazoxiben significantly reduced plasma thromboxane levels in all patients. 3 Dazoxiben had no adverse effect on coronary and systemic haemodynamics, and atrial pacing time to angina was increased from 245 +/- 41 to 308 +/- 48s (P less than 0.01).
摘要
- 在稳定型心绞痛患者诱发心绞痛时以及不稳定型心绞痛患者服用100毫克达唑氧苯前后，分别从冠状窦和主动脉获取血浆血栓素水平。2. 尽管不同组的值范围较宽，但达唑氧苯显著降低了所有患者的血浆血栓素水平。3. 达唑氧苯对冠状动脉和全身血流动力学无不良影响，心绞痛发作的心房起搏时间从245±41秒增加到308±48秒（P<0.01）。
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