达唑氧苯在静息及心房起搏时的血流动力学和代谢效应。
Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing.
作者信息
Kiff P S, Bergman G, Atkinson L, Jewitt D E, Westwick J, Kakkar V V
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):73S-77S. doi: 10.1111/j.1365-2125.1983.tb02112.x.
Abstract
1 Thromboxane B2 (TXB2) levels were measured in three sites (coronary sinus, pulmonary artery, and femoral artery) at rest and during atrial pacing in 11 patients with stable angina pectoris. 2 There was a highly significant increase in arterial TXB2 on pacing (by up to 820 pg/ml) but there was no change in the thromboxane levels at the other two sites. 3 Dazoxiben 200 mg orally abolished the increase in arterial TXB2, but had no effect on systemic, pulmonary or coronary haemodynamics, no effect on myocardial metabolism and a variable effect on atrial pacing time to angina.
摘要
- 在11例稳定型心绞痛患者静息状态及心房起搏期间，于三个部位（冠状窦、肺动脉和股动脉）测定了血栓素B2（TXB2）水平。2. 起搏时动脉TXB2显著升高（最高达820 pg/ml），但其他两个部位的血栓素水平无变化。3. 口服200 mg达唑氧苯可消除动脉TXB2的升高，但对全身、肺或冠状动脉血流动力学无影响，对心肌代谢无影响，对心房起搏诱发心绞痛的时间影响不一。
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