慢性乙醇处理期间小鼠突触膜表面糖缀合物增加。
Increased surface glycoconjugates of synaptic membranes in mice during chronic ethanol treatment.
作者信息
Goldstein D B, Hungund B L, Lyon R C
出版信息
Br J Pharmacol. 1983 Jan;78(1):8-10. doi: 10.1111/j.1476-5381.1983.tb09356.x.
Abstract
Synaptosomal plasma membranes from mice treated chronically with ethanol were incubated with galactose oxidase and [3H]-sodium borohydride, in order to label the exposed galactose and N-acetylgalactosamine groups of glycoconjugates. The ethanol treatment approximately doubled the amount of exposed sugars. This change may be related to previously observed alterations in the physical properties of neuronal membranes in ethanol-treated mice.
摘要
用乙醇长期处理的小鼠的突触体细胞膜与半乳糖氧化酶和[3H]硼氢化钠一起孵育，以便标记糖缀合物中暴露的半乳糖和N-乙酰半乳糖胺基团。乙醇处理使暴露的糖量增加了约一倍。这种变化可能与先前观察到的乙醇处理小鼠神经元膜物理性质的改变有关。
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