Deitrich R A
University of Colorado Alcohol Research Center, Department of Pharmacology, Denver 80262.
Behav Genet. 1993 Mar;23(2):153-62. doi: 10.1007/BF01067420.
Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the causes of the genetic predisposition of humans to alcoholism. Eventually it is envisioned that the synteny between the mouse and human genomes will allow identification of specific genes responsible for acute effects of ethanol in both species as well as clues as to how alcoholism in humans can be better identified, prevented, and treated.
为了研究乙醇对哺乳动物中枢神经系统产生众多影响的机制，许多研究人员对乙醇初始敏感性进行了选择性育种。此外，这些选择性育种动物的存在为人类酒精中毒遗传易感性的原因提供了线索。最终，可以设想，小鼠和人类基因组之间的同线性将有助于识别对两个物种中乙醇急性效应负责的特定基因，以及如何更好地识别、预防和治疗人类酒精中毒的线索。
