Tenforde T S, Adesida P O, Kelly L S, Todd P W
Eur J Cancer Clin Oncol. 1983 Feb;19(2):277-82. doi: 10.1016/0277-5379(83)90427-3.
Comparative measurements have been made of the transplantation and electrical surface charge properties of the near-diploid TA3-Ha ascites tumor and a new hypotetraploid ascites subline designated TA3-L. The negative surface charge density and the density of electrophoretically detectable sialic acid residues were determined to be twice as great for TA3-L as TA3-Ha cells. The two TA3 sublines were found to have identical growth properties in isogeneic mice and to exhibit progressive growth in three allogeneic strains of mice. The lethal tumor cell inoculum in allogeneic mice was lower in all cases for the TA3-L cells. From a comparison of several TA3 ascites tumor sublines, it can be concluded that their transplantability into allogeneic strains of mice is correlated with the density of negative surface charge but is independent of the degree of tumor aneuploidy.
已对近二倍体TA3-Ha腹水瘤和新的次四倍体腹水亚系TA3-L的移植和表面电荷特性进行了比较测量。结果表明，TA3-L细胞的负表面电荷密度和电泳可检测的唾液酸残基密度是TA3-Ha细胞的两倍。发现这两个TA3亚系在同基因小鼠中具有相同的生长特性，并在三种异基因小鼠品系中呈现渐进性生长。在所有情况下，TA3-L细胞在异基因小鼠中的致死肿瘤细胞接种量都较低。通过对几种TA3腹水瘤亚系的比较可以得出结论，它们在异基因小鼠品系中的移植能力与负表面电荷密度相关，但与肿瘤非整倍体程度无关。
