Bourgeois B F, Dodson W E, Ferrendelli J A
Neurology. 1983 Mar;33(3):283-90. doi: 10.1212/wnl.33.3.283.
Neurotoxicity and protection against maximal electroshock and Metrazol seizures from primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA) were determined in mice for each drug separately and expressed in terms of brain concentrations. Compared with PB, PEMA was 16 times less potent against electroshock and Metrazol seizures but only 8 times less toxic. Primidone was markedly less neurotoxic than PB and equally potent against electroshock, but PRM had no effect against Metrazol or bicuculline. PRM is a relatively nontoxic anticonvulsant with a different action than PB, and PEMA is both a weak and a relatively toxic anticonvulsant.
分别测定了小鼠体内扑米酮（PRM）、苯巴比妥（PB）和苯乙基丙二酰胺（PEMA）的神经毒性以及对最大电休克和戊四氮惊厥的保护作用，并以脑内浓度表示。与PB相比，PEMA对电休克和戊四氮惊厥的效力低16倍，但毒性仅低8倍。扑米酮的神经毒性明显低于PB，对电休克的效力相同，但PRM对戊四氮或荷包牡丹碱无作用。PRM是一种相对无毒的抗惊厥药，其作用与PB不同，而PEMA既是一种弱效又是一种相对有毒的抗惊厥药。
