家禽的癫痫样发作。VIII. 扑米酮及其代谢产物苯巴比妥和苯乙丙二酰胺的抗惊厥活性。
Epileptiform seizures in domestic fowl. VIII. Anticonvulsant activity of primidone and its metabolites, phenobarbital and phenylethylmalonamide.
作者信息
Johnson D D, Davis H L, Crawford R D
出版信息
Can J Physiol Pharmacol. 1978 Aug;56(4):630-3. doi: 10.1139/y78-100.
DOI:10.1139/y78-100
PMID:688087
Abstract
Primidone is an effective anticonvulsant against seizures induced in epileptic fowl by exposure to intermittent photic stimulation. Epileptic fowl metabolize primidone to phenobarbital. Pretreatment of epileptic fowl with SKF 525A to prevent the metabolism of primidone to phenobarbital indicated that primidone itself had anticonvulsant activity. Phenylethylmalonamide, a second metabolite of primidone, did not have anticonvulsant activity when administered at the same dose as primidone.
摘要
扑米酮是一种有效的抗惊厥药物，可对抗暴露于间歇性光刺激下的癫痫鸡诱发的癫痫发作。癫痫鸡将扑米酮代谢为苯巴比妥。用SKF 525A预处理癫痫鸡以阻止扑米酮代谢为苯巴比妥，这表明扑米酮本身具有抗惊厥活性。苯乙丙二酰胺是扑米酮的第二种代谢产物，当以与扑米酮相同的剂量给药时，它没有抗惊厥活性。
相似文献
1
Epileptiform seizures in domestic fowl. VIII. Anticonvulsant activity of primidone and its metabolites, phenobarbital and phenylethylmalonamide.家禽的癫痫样发作。VIII. 扑米酮及其代谢产物苯巴比妥和苯乙丙二酰胺的抗惊厥活性。
Can J Physiol Pharmacol. 1978 Aug;56(4):630-3. doi: 10.1139/y78-100.
2
Effects of primidone, phenobarbital and phenylethylmalonamide in the stimulated frog neuromuscular junction.扑米酮、苯巴比妥和苯乙基丙二酰胺对刺激的青蛙神经肌肉接头的作用。
J Pharmacol Exp Ther. 1984 Jan;228(1):121-7.
3
4
Study of the hepatic metabolism of primidone by improved methodology.采用改进方法对扑米酮的肝脏代谢进行研究。
J Pharmacol Exp Ther. 1975 Jul;194(1):117-25.
5
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Ther Drug Monit. 1986;8(2):161-5. doi: 10.1097/00007691-198606000-00006.
6
Serum concentrations of primidone and its metabolites, phenylethylmalonamide and phenobarbital, in the dog.犬体内扑米酮及其代谢产物苯乙基丙二酰胺和苯巴比妥的血清浓度。
Am J Vet Res. 1980 Oct;41(10):1643-5.
7
Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.癫痫犬体内扑米酮及其代谢产物苯巴比妥和苯乙丙二酰胺的治疗血清浓度。
J Am Vet Med Assoc. 1983 May 15;182(10):1091-4.
8
Epileptiform seizures in domestic fowl. VI. Plasma phenobarbital concentrations and anticonvulsant activity.家禽的癫痫样发作。VI. 血浆苯巴比妥浓度和抗惊厥活性。
Can J Physiol Pharmacol. 1977 Aug;55(4):848-54. doi: 10.1139/y77-114.
9
Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice.
Ann Neurol. 1979 May;5(5):470-4. doi: 10.1002/ana.410050512.
10
Metabolism and anticonvulsant properties of primidone in the rat.扑米酮在大鼠体内的代谢及抗惊厥特性
J Pharmacol Exp Ther. 1973 Aug;186(2):305-14.
引用本文的文献
1
Blood and cerebrospinal fluid pharmacokinetics of primidone and its primary pharmacologically active metabolites, phenobarbital and phenylethylmalonamide in the rat.扑米酮及其主要药理活性代谢产物苯巴比妥和苯乙基丙二酰胺在大鼠体内的血液和脑脊液药代动力学
Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):255-64. doi: 10.1007/BF03190029.
2
Formation of active metabolites of anticonvulsant drugs. A review of their pharmacokinetic and therapeutic significance.抗惊厥药物活性代谢物的形成。其药代动力学及治疗意义综述。
Clin Pharmacokinet. 1991 Jul;21(1):27-41. doi: 10.2165/00003088-199121010-00003.
Zotero 插件