通过血浆置换和免疫抑制治疗肺出血肾炎综合征。
Treatment of Goodpasture's disease by plasma exchange and immunosuppression.
作者信息
Swainson C P, Robson J S, Urbaniak S J, Keller A J, Kay A B
出版信息
Clin Exp Immunol. 1978 May;32(2):233-42.
Abstract
Three cases of Goodpasture's disease are described who were treated with intensive plasma exchange and immunosuppression. There was no improvement in renal function and the patients required chronic haemodialysis, but renal function did recover with treatment for recurrence of disease in a transplanted kidney. Anti-GBM antibody levels were not controlled and substantial reduction in fibrinogen and complement were only achieved with daily treatment. A controlled trial of this regime is urgently required.
摘要
本文描述了3例采用强化血浆置换和免疫抑制治疗的肺出血肾炎综合征患者。其肾功能未得到改善，患者需要长期进行血液透析，但在移植肾疾病复发接受治疗后肾功能得以恢复。抗肾小球基底膜（GBM）抗体水平未得到控制，仅通过每日治疗才使纤维蛋白原和补体大幅降低。迫切需要对该治疗方案进行对照试验。
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