给豚鼠持续喂食牛奶后对过敏性休克的耐受性
Refractoriness to anaphylactic shock after continuous feeding of cow's milk to guinea-pigs.
作者信息
Coombs R R, Devey M E, Anderson K J
出版信息
Clin Exp Immunol. 1978 May;32(2):263-71.
Further studies have been undertaken on the anaphylactic sensitization to cows' milk in guinea-pigs given cows' milk to drink instead of water. With continuous feeding over a prolonged period of time (over 70 days), about 70% of the guinea-pigs became refractory to intratracheal challenge of cows' milk and about 30% to intravenous challenge. Some guinea-pigs given cows' milk from the second day of life appeared not to undergo an early sensitization at all and may have been displaying a tolerance to anaphylactic sensitization. The degree to which this was shown may be genetic. The anaphylactic sensitivity, particularly as regards intravenous challenge, could be assessed by examining the sera for IgGl a antibodies to cows' milk by passive cutaneous anaphylaxis.
对用牛奶而非水喂养的豚鼠进行了关于牛奶过敏致敏的进一步研究。在长时间（超过70天）持续喂食后，约70%的豚鼠对气管内注入牛奶激发产生耐受，约30%的豚鼠对静脉注射激发产生耐受。一些从出生第二天就开始喂牛奶的豚鼠似乎根本没有经历早期致敏，可能表现出对过敏致敏的耐受性。这种耐受性表现的程度可能具有遗传性。过敏敏感性，尤其是静脉注射激发方面的敏感性，可以通过被动皮肤过敏反应检测血清中针对牛奶的IgGl a抗体来评估。
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