Kandan S, Gopalakrishnan V, Govindarajulu P, Indira R, Malathi T
Horm Res. 1983;17(2):93-102. doi: 10.1159/000179682.
Bromocriptine suppressed lactation by depressing the serum prolactin (PRL) level in 10 of 12 cases with profuse galactorrhea. The PRL level in galactorrhea milk was lower than in serum and was similar to that obtained in normal mature milk. However, significantly higher total solid, total ash, lipid and calcium levels, and reduced lactose and potassium levels were seen in galactorrhea specimens compared to mature milk. Although all the constituents decreased during treatment, the highly significant reduction in lipid and calcium levels shows the predominant effect of PRL on mammary synthesis and/or transport of these constituents. Fasting serum total lipids, total cholesterol and triglyceride levels were significantly higher in the galactorrhea group than in breast-feeding women with established lactation, suggesting that elevated serum PRL plays a role in lipid metabolism.
溴隐亭可通过降低血清催乳素（PRL）水平来抑制12例溢乳症患者中10例的泌乳。溢乳中的PRL水平低于血清中的水平，且与正常成熟乳汁中的PRL水平相似。然而，与成熟乳汁相比，溢乳样本中的总固体、总灰分、脂质和钙水平显著更高，而乳糖和钾水平则降低。尽管治疗期间所有成分均减少，但脂质和钙水平的极显著降低表明PRL对这些成分的乳腺合成和/或转运具有主要作用。溢乳症组的空腹血清总脂质、总胆固醇和甘油三酯水平显著高于已建立泌乳的哺乳期妇女，这表明血清PRL升高在脂质代谢中起作用。
