Peters F, Geisthövel F, Breckwoldt M
Acta Endocrinol (Copenh). 1985 Aug;109(4):463-6. doi: 10.1530/acta.0.1090463.
Serum prolactin levels and milk yield were studied in 27 puerperae with excessive milk production (polygalactia) and compared with 30 normally lactating puerperae. In order to normalize polygalactia, 14 of these women were treated with 2.5 mg bromocriptine per day for 3 days starting on post-partum day 5, 13 women received placebo. Milk flow in polygalactic women started significantly earlier than in puerperae with normal milk yield and developed mean milk volumes of 816 g per day on post-partum day 4. Serum prolactin levels did not differ from levels of puerperae with normal milk yield. There was no correlation between serum prolactin and milk yield. Bromocriptine treatment resulted in a sharp but reversible decline of serum prolactin levels followed by a significant reduction of milk production. Bromocriptine could not be detected in milk specimens, while serum levels showed significant amounts. In placebo treated women prolactin levels and milk yield remained unaffected. These data indicate that serum prolactin concentrations of puerperae with polygalactia are within the normal post-partum range. Short term prolactin suppression by bromocriptine can reduce milk yield, without complete ablactation.
对27名乳汁分泌过多（多乳症）的产妇的血清催乳素水平和产奶量进行了研究，并与30名正常哺乳的产妇进行了比较。为了使多乳症恢复正常，其中14名女性从产后第5天开始每天服用2.5毫克溴隐亭，持续3天，13名女性接受安慰剂。多乳症女性的乳汁分泌开始时间明显早于产奶量正常的产妇，在产后第4天平均每天产奶量达816克。血清催乳素水平与产奶量正常的产妇的水平没有差异。血清催乳素与产奶量之间没有相关性。溴隐亭治疗导致血清催乳素水平急剧但可逆地下降，随后产奶量显著减少。在乳汁样本中未检测到溴隐亭，而血清中显示有大量溴隐亭。在接受安慰剂治疗的女性中，催乳素水平和产奶量未受影响。这些数据表明，多乳症产妇的血清催乳素浓度在产后正常范围内。溴隐亭短期抑制催乳素可减少产奶量，但不会完全回奶。
