Spontaneous oral-facial dyskinesia: neuropathology of a case.

The neuropathologic findings in a previously reported patient with spontaneous oral-facial dyskinesia are presented. The main microscopic abnormalities were limited to the dorsal halves of the caudate and putamen, which showed a unique pattern of neuronal cell loss and severe gliosis, giving a mosaic appearance. These findings differ from those of other known hereditary or acquired involuntary movement disorders.