Lueck C J, Tanyeri S, Crawford T J, Elston J S, Kennard C
Department of Neurology, London Hospital, Whitechapel, UK.
J Neurol. 1990 Jul;237(4):226-9. doi: 10.1007/BF00314623.
To provide evidence of an organic pathology for essential (idiopathic) blepharospasm, reflex saccadic eye movements in response to randomly stepped visual targets were assessed in seven affected patients and seven age-matched controls using the magnetic scleral search coil technique. The results indicate a significant prolongation in latency and a reduction in gain of horizontal saccades, and an increase in latency and reduction of peak velocity of large downward saccades. These findings suggest an organic component to the aetiology of blepharospasm, the pathology of which also appears to involve the oculomotor system. The pattern of the oculomotor disorder does not allow specific localisation but is consistent with the underlying pathology being localised in the basal ganglia.
为了提供原发性（特发性）睑痉挛存在器质性病变的证据，我们使用磁巩膜搜索线圈技术，对7例患病患者和7名年龄匹配的对照者进行了评估，以检测他们对随机阶梯式视觉目标做出反应时的反射性眼球扫视运动。结果表明，水平扫视的潜伏期显著延长，增益降低，大的向下扫视的潜伏期增加，峰值速度降低。这些发现提示睑痉挛病因中存在器质性成分，其病理似乎也涉及动眼系统。动眼障碍的模式无法进行具体定位，但与潜在病变定位于基底神经节一致。
