Czaja J A
Physiol Behav. 1983 Feb;30(2):197-201. doi: 10.1016/0031-9384(83)90005-7.
Relationships between endocrine state, body weight, and vaginal membrane condition were evaluated in two studies. In the first study, vaginal membrane and body weight of 15 pregnant subjects were monitored from the ovarian cycle of conception through parturition. There was a significant depression in body weight of 13.3 +/- 3.1 g coincident with vaginal membrane rupture at the estimated time of conception. A second instance of vaginal membrane rupture was found to occur during midpregnancy in 14 of the females. At that time, female body weight showed a significant relative decline of 12.9 +/- 2.4 g. In the second study, treatment of ovariectomized females with estradiol benzoate readily produced rupture of the vaginal membrane and suppressed body weight by 17.9 +/- 1.8 g. It is therefore hypothesized that the observed midpregnancy changes in vaginal membrane condition and body weight identify an interval of increased estrogen stimulation sufficient to produce physiological and behavioral effects in pregnant guinea pigs. Such effects are not readily explained by reference to levels of circulating estrogens or progesterone during pregnancy and therefore may reflect changes in plasma or tissue binding of these steroids.
在两项研究中评估了内分泌状态、体重与阴道膜状况之间的关系。在第一项研究中，对15名怀孕受试者从受孕的卵巢周期到分娩期间的阴道膜和体重进行了监测。在估计的受孕时间，体重显著下降了13.3±3.1克，同时阴道膜破裂。在14只雌性动物的妊娠中期发现了第二次阴道膜破裂。当时，雌性动物的体重显著相对下降了12.9±2.4克。在第二项研究中，用苯甲酸雌二醇治疗去卵巢雌性动物，很容易导致阴道膜破裂，并使体重减轻了17.9±1.8克。因此，据推测，观察到的妊娠中期阴道膜状况和体重的变化表明，雌激素刺激增加的时间段足以在怀孕的豚鼠身上产生生理和行为影响。这些影响不能通过参考怀孕期间循环雌激素或孕酮的水平轻易解释，因此可能反映了这些类固醇在血浆或组织中的结合变化。
