Lewensohn R, Tribukait B, Hansson J
Eur J Cancer Clin Oncol. 1983 Jan;19(1):59-63. doi: 10.1016/0277-5379(83)90399-1.
DNA flow cytofluorometry of bone marrow cells from 29 patients with multiple myeloma disclosed a 55% incidence of aneuploid cell populations with a DNA index between the diploid and the tetraploid regions (2-4 C) and a mean value of 2.5 C. The bone marrow of these patients demonstrated a correlation between the proportion of aneuploid and morphologically identifiable myeloma cells, which indicates a monoclonal pattern in the aneuploid cases without additional diploid myeloma cell clones. In the present patient material no statistically significant relation was found between diploid and aneuploid cases as regards the type of monoclonal immunoglobulin. Further, there was no difference between the diploid and aneuploid cases as regards myeloma cell differentiation, myeloma cell [3H]-thymidine labeling index or response to melphalan treatment.
对29例多发性骨髓瘤患者的骨髓细胞进行DNA流式细胞荧光分析发现，非整倍体细胞群的发生率为55%，其DNA指数介于二倍体和四倍体区域之间（2 - 4C），平均值为2.5C。这些患者的骨髓显示，非整倍体与形态学上可识别的骨髓瘤细胞比例之间存在相关性，这表明在非整倍体病例中存在单克隆模式，而没有额外的二倍体骨髓瘤细胞克隆。在本患者材料中，就单克隆免疫球蛋白类型而言，二倍体和非整倍体病例之间未发现统计学上的显著关系。此外，在骨髓瘤细胞分化、骨髓瘤细胞[3H] - 胸腺嘧啶核苷标记指数或对美法仑治疗的反应方面，二倍体和非整倍体病例之间没有差异。
