Grubeck-Loebenstein B, Kronik G, Mösslacher H, Waldhäusl W
Exp Clin Endocrinol. 1983 Jan;81(1):59-64. doi: 10.1055/s-0029-1210207.
Application of large amounts of iodine in the form of amidotricoic acid (Urografin) in 20 patients undergoing coronary angiography led to an increase in serum thyroxine (T4, p less than 0.005), triiodothyronine (T3, p less than 0.005) and plasma thyrotropin (TSH) in the basal state (p less than 0.05) as well as after TRH-stimulation (p less than 0.05), but not of serum 3,3',5'-triiodothyronine (reverse-T3, rT3) three weeks after contrast medium administration. Although TRH induced TSH stimulation had been subnormal prior to contrast medium application in five patients, T4 as well as T3 remained within the normal range in all patients. Neither preexisting iodine excretion nor the amount of contrast medium applied were related with the observed hormonal changes. We conclude, that application of relatively small as well as large amounts of amidotricoic acid leads to an increase of peripheral thyroid hormone concentrations, paralleled by a rise in basal and stimulated TSH secretion. These changes may be interpreted as physiological adaptation to augmented iodine supply in an area of moderate iodine deficiency.
对20例接受冠状动脉造影的患者应用大量氨三碘苯甲酸（泛影葡胺）造影剂，导致基础状态下血清甲状腺素（T4，P<0.005）、三碘甲状腺原氨酸（T3，P<0.005）和血浆促甲状腺激素（TSH）升高（P<0.05），促甲状腺激素释放激素（TRH）刺激后也升高（P<0.05），但造影剂给药三周后血清3,3',5'-三碘甲状腺原氨酸（反式T3，rT3）未升高。尽管在5例患者中，造影剂应用前TRH诱导的TSH刺激低于正常水平，但所有患者的T4和T3仍在正常范围内。既往碘排泄情况和所用造影剂的量均与观察到的激素变化无关。我们得出结论，应用相对少量和大量的氨三碘苯甲酸都会导致外周甲状腺激素浓度升高，同时基础和刺激后的TSH分泌增加。这些变化可解释为在碘轻度缺乏地区对碘供应增加的生理适应。
