在多胺依赖的中国仓鼠卵巢（CHO）细胞株中，多胺饥饿会导致细胞核和染色体畸变同时增加。
Polyamine starvation causes parallel increase in nuclear and chromosomal aberrations in a polyamine-dependent strain of CHO.
作者信息
Knuutila S, Pohjanpelto P
出版信息
Exp Cell Res. 1983 Apr 15;145(1):222-6. doi: 10.1016/s0014-4827(83)80024-x.
PMID:6682797
Abstract
Deprivation of polyamines and ornithine causes in a polyamine-dependent CHO strain aneuploidy and alterations in nuclear morphology including micronuclei, macronuclei, framented and bulged nuclei. There is also formation of multinucleate cells. The number of micronuclei and certain other nuclear aberrations increase concomitantly with chromosome abberrations.
摘要
在一个多胺依赖性的中国仓鼠卵巢（CHO）细胞株中，多胺和鸟氨酸的缺乏会导致非整倍体以及核形态的改变，包括微核、巨核、核碎片化和核凸起。还会形成多核细胞。微核的数量和某些其他核异常与染色体畸变同时增加。
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