Yoshimura H, Ogawa N
Nihon Yakurigaku Zasshi. 1983 Feb;81(2):135-41.
The present study was conducted to investigate the effect of ethylalcohol on agonistic behavior using a resident-intruder paradigm. In this paradigm, a resident male mouse has been cohabiting with a female for 5 weeks, and an intruder male mouse is introduced into the resident's home cage. The effects of four doses of ethylalcohol (vehicle, 0.5, 1.0, and 2.0 g/kg, p.o.) were assessed in resident mice and group-housed intruder mice. Residents and intruders were drugged on alternate test days, and all animals received different sequences of drug conditions according to a random schedule. When resident mice were treated with ethylalcohol biphasic effects on resident's aggressive elements were observed: 0.5 and 1.0 g/kg of ethylalcohol increased attack bitings and sideways posture, while 2.0 g/kg of the drug suppressed aggressive elements. On the other hand, when intruder mice were drugged the resident's attack bitings were significantly increased in a dose-dependent manner. At this time, defensive upright postures of intruder mice were suppressed by the drug. Ethylalcohol at the employed doses did not affect locomotor activity in both resident and intruder mice. The results suggest that ethylalcohol enhances the hostility of resident to the intruding animal and suppresses the anxiety of an intruder to the attacking animal.
本研究旨在使用定居者-入侵者范式研究乙醇对攻击行为的影响。在该范式中，一只雄性定居小鼠与一只雌性小鼠共同生活5周，然后将一只雄性入侵者小鼠引入定居者的笼舍。评估了四种剂量的乙醇（溶剂对照、0.5、1.0和2.0 g/kg，口服）对定居小鼠和群居入侵者小鼠的影响。定居者和入侵者在交替的测试日给药，所有动物根据随机时间表接受不同顺序的药物处理。当给定居小鼠使用乙醇时，观察到对定居者攻击行为的双相影响：0.5和1.0 g/kg的乙醇增加了攻击咬伤和侧身姿势，而2.0 g/kg的药物抑制了攻击行为。另一方面，当给入侵者小鼠给药时，定居者的攻击咬伤以剂量依赖性方式显著增加。此时，药物抑制了入侵者小鼠的防御直立姿势。所用剂量的乙醇对定居小鼠和入侵者小鼠的运动活动均无影响。结果表明，乙醇增强了定居者对入侵动物的敌意，并抑制了入侵者对攻击动物的焦虑。
