Yoshimura H, Ogawa N
Jpn J Pharmacol. 1982 Dec;32(6):1111-6. doi: 10.1254/jjp.32.1111.
The resident-intruder paradigm was employed in order to evoke an agonistic behavior in mice. In this situation a resident male mouse has been cohabiting with a female for 5 weeks, and an intruder male mouse is introduced into the resident's home cage. A species-specific pattern of agonistic behavior was observed in all mice. The significance of cholinergic mechanisms in the mediation of the agonistic behavior was evaluated by pharmacological manipulations. Drugs were administered to resident mice. Scopolamine hydrobromide (0.25, 0.50 and 0.75 mg/kg, i.p.) significantly suppressed the resident's aggressive episodes (offensive sideways posture, tail rattling and attack biting) in a dose-dependent manner, whereas the peripheral anticholinergic drug methylscopolamine nitrate (0.25, 0.50 and 0.75 mg/kg, i.p.) was ineffective. On the other hand, the resident's locomotor activity and rearing response were significantly increased after the administration of scopolamine hydrobromide. The evidence suggests that brain cholinoceptive mechanisms may participate in the regulation of intraspecies aggressive behavior. However, it appears that other nonspecific behavioral effects of scopolamine cannot be ruled out.
采用定居者-入侵者范式来诱发小鼠的攻击行为。在这种情况下，一只雄性定居小鼠与一只雌性小鼠共同生活5周，然后将一只雄性入侵者小鼠放入定居者的笼舍中。在所有小鼠中均观察到了物种特异性的攻击行为模式。通过药理学操作评估胆碱能机制在介导攻击行为中的作用。给定居小鼠给药。氢溴酸东莨菪碱（0.25、0.50和0.75毫克/千克，腹腔注射）以剂量依赖的方式显著抑制了定居者的攻击行为（攻击性侧姿、尾巴摆动和攻击撕咬），而外周抗胆碱能药物硝酸甲基东莨菪碱（0.25、0.50和0.75毫克/千克，腹腔注射）则无效。另一方面，氢溴酸东莨菪碱给药后，定居者的运动活动和竖毛反应显著增加。有证据表明，脑胆碱感受机制可能参与种内攻击行为的调节。然而，似乎不能排除东莨菪碱的其他非特异性行为效应。
