Winkelmann R K, Thomas J R, Randle H W
Cutis. 1983 Jun;31(6):621-32.
A patient with short-duration pityriasis rubra pilaris was successfully treated with high-dose, toxic vitamin A (retinol), but the disease subsequently recurred in new areas. Serum levels of vitamin A were highest four hours after treatment and returned to the base level within twelve hours. Fasting blood levels of vitamin A during treatment increased to five times the pretreatment level. Ultrastructural changes in the keratinocytes were notable vacuolation, granularity of the cytoplasm, and a decrease in tonofilament masses, all indications of the cellular effect of the vitamin A. We believe that patients with long-duration pityriasis rubra pilaris should be considered for this treatment.
一名患有短期毛发红糠疹的患者接受高剂量、有毒性的维生素A（视黄醇）治疗后取得成功，但疾病随后在新的部位复发。维生素A的血清水平在治疗后四小时最高，并在十二小时内恢复到基线水平。治疗期间空腹血中维生素A水平升至治疗前水平的五倍。角质形成细胞的超微结构变化显著，有细胞空泡化、细胞质颗粒化以及张力丝束减少，这些都是维生素A细胞效应的表现。我们认为，对于患有长期毛发红糠疹的患者应考虑采用这种治疗方法。
