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[用于计算任意系谱中基因同源身份概率的算法]

[Algorithm for calculating the probabilities of the identity of genes by descent in arbitrary pedigrees].

作者信息

Ageev S V

出版信息

Genetika. 1983 Apr;19(4):670-8.

PMID:6683213
Abstract

For an arbitrary locus (autosomal or X-linked), comprehensive enumeration of different variants of genes' identity by descent for two individuals is given. The algorithm for computation of probability of every variant is described for any two individuals in arbitrary pedigree. On the basis of the algorithm proposed, the problem of computation of Malecot's "coefficient de parente" and inbreeding coefficient is solved under sex-linked transmission. It has been also shown that the approach described is the most common method for solution of a problem of partitioning of covariances among relatives on genotypic components of the variance.

摘要

对于任意基因座(常染色体或X连锁),给出了两个个体按血统计算基因身份不同变体的全面枚举。描述了在任意系谱中计算任意两个个体每种变体概率的算法。基于所提出的算法,解决了性连锁遗传情况下Malecot“亲缘系数”和近亲繁殖系数的计算问题。还表明,所描述的方法是解决亲属间协方差按方差的基因型成分进行划分问题的最常用方法。

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