Whittemore A S, Halpern J
Department of Health Research and Policy, Stanford University School of Medicine, California 94305.
Biometrics. 1994 Mar;50(1):109-17.
Two genes at a given locus are identical by descent (IBD) if both have been inherited from a common ancestor. We present an algorithm for computing the probabilities of all IBD relationships among the genes of pedigree members. We show how to use these probabilities to calculate the probability of any combination of genotypes or phenotypes for the pedigree members. Applications to linkage analysis and genetic counseling are illustrated with examples. The algorithm also can be used to calculate the generalized kinship coefficients proposed by others.
如果给定基因座上的两个基因均从共同祖先遗传而来，则它们是同源相同（IBD）的。我们提出了一种算法，用于计算家系成员基因间所有IBD关系的概率。我们展示了如何使用这些概率来计算家系成员任何基因型或表型组合的概率。通过实例说明了该算法在连锁分析和遗传咨询中的应用。该算法还可用于计算其他人提出的广义亲缘系数。
