Menne T, Mikkelsen H I, Solgaard P
Contact Dermatitis. 1978 Apr;4(2):106-8. doi: 10.1111/j.1600-0536.1978.tb03743.x.
In recent years the importance of internal exposure to nickel in patients with recurrent hand eczema and nickel allergy has become evident. The present study was performed in order to investigate the value of urinary nickel determinations as an index of oral nickel intake. After oral administration of 5.6 mg nickel (as the sulfate), increased nickel excretion was found over the following 2-3 days. We conclude that consecutive urinary nickel determinations are able to disclose variations in oral intake of nickel.
近年来，反复手部湿疹和镍过敏患者体内镍暴露的重要性已变得明显。本研究旨在探讨尿镍测定作为口服镍摄入量指标的价值。口服5.6毫克镍（以硫酸盐形式）后，在接下来的2至3天内发现尿镍排泄增加。我们得出结论，连续的尿镍测定能够揭示口服镍摄入量的变化。
