Christensen O B, Lagesson V
Ann Clin Lab Sci. 1981 Mar-Apr;11(2):119-25.
Nickel concentration in serum and whole blood as well as nickel excretion in urine was assayed at different time intervals before and after ingestion of nickel sulfate in eight healthy volunteers during a three days study. The peak level of nickel in blood was reached 2.5 hours after nickel ingestion and the maximal urinary excretion of nickel was during the first eight hours after ingestion. Great individual variations in nickel concentrations in blood and nickel excretion in urine were observed. Analysis of nickel in both urine and serum reflects ingestion of a soluble nickel salt, but urine seems to be most reliable to follow.
在一项为期三天的研究中，对8名健康志愿者在摄入硫酸镍之前和之后的不同时间间隔测定了血清和全血中的镍浓度以及尿中的镍排泄量。摄入镍后2.5小时达到血液中镍的峰值水平，摄入后前8小时为尿中镍的最大排泄期。观察到血液中镍浓度和尿中镍排泄量存在很大的个体差异。尿液和血清中的镍分析均反映了可溶性镍盐的摄入情况，但尿液似乎是最可靠的跟踪指标。
