Crabbe J C, Kosobud A, Young E R, Janowsky J S
Neurobehav Toxicol Teratol. 1983 Mar-Apr;5(2):181-7.
Male mice of parent inbred strains C57BL/6J and DBA/2J, and mice from several of the BXD/Ty Recombinant Inbred (RI) strains derived from the cross of the parent inbred strains were tested for responsiveness to ethanol. Separate groups of mice from these strains were characterized for sensitivity to ethanol's effects to increase activity in an open field and to induce ambulatory ataxia in the grid test. The strain distribution pattern of the RI strains indicated polygenic control of both responses to ethanol. Other mice from this battery were tested for acceptance of an ethanol solution, a measure related to preference drinking. This trait may be substantially influenced by a single gene. Mice were then rendered physically dependent on ethanol through inhalation of ethanol vapor for three days. Severity of handling-induced convulsions was used to index the severity of the ethanol withdrawal syndrome. The distribution of the RI strains indicated possible influence of a major gene on ethanol withdrawal severity.
对亲代近交系C57BL/6J和DBA/2J的雄性小鼠，以及来自亲代近交系杂交产生的几个BXD/Ty重组近交（RI）品系的小鼠进行了乙醇反应测试。从这些品系中选取不同组的小鼠，测定它们对乙醇在旷场中增加活动以及在网格试验中诱发行走性共济失调作用的敏感性。RI品系的品系分布模式表明，对乙醇的这两种反应均受多基因控制。对该组中的其他小鼠进行了乙醇溶液接受度测试，这是一项与偏好饮酒相关的指标。该性状可能受单个基因的显著影响。然后通过吸入乙醇蒸汽三天使小鼠对乙醇产生身体依赖性。用处理诱导惊厥的严重程度来衡量乙醇戒断综合征的严重程度。RI品系的分布表明，一个主要基因可能对乙醇戒断严重程度有影响。
