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溶液中黏液糖蛋白的灵活且高度扩展的球状模型的进一步证据。

Further evidence for a flexible and highly expanded spheroidal model for mucus glycoproteins in solution.

作者信息

Harding S E, Rowe A J, Creeth J M

出版信息

Biochem J. 1983 Mar 1;209(3):893-6. doi: 10.1042/bj2090893.

DOI:10.1042/bj2090893
PMID:6683504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1154172/
Abstract

The flexible and greatly expanded roughly spherical model for mucus glycoproteins proposed earlier, on the basis of hydrodynamic and n.m.r. data, is supported by new hydrodynamic results on a bronchial glycoprotein from a cystic-fibrosis patient. Furthermore, images from electron microscopy of this molecule and a lower-molecular-weight mucus glycoprotein (which closely resembles a glycopolypeptide) appear to be at least consistent with this model.

摘要

基于流体动力学和核磁共振数据,先前提出的黏液糖蛋白的灵活且大幅扩展的大致球形模型,得到了来自一名囊性纤维化患者的支气管糖蛋白新流体动力学结果的支持。此外,该分子以及一种低分子量黏液糖蛋白(其与糖多肽非常相似)的电子显微镜图像似乎至少与该模型相符。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9fc/1154172/0919c723e683/biochemj00358-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9fc/1154172/9af2e1a39d55/biochemj00358-0320-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9fc/1154172/0919c723e683/biochemj00358-0321-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9fc/1154172/9af2e1a39d55/biochemj00358-0320-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9fc/1154172/0919c723e683/biochemj00358-0321-a.jpg

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1
Further evidence for a flexible and highly expanded spheroidal model for mucus glycoproteins in solution.溶液中黏液糖蛋白的灵活且高度扩展的球状模型的进一步证据。
Biochem J. 1983 Mar 1;209(3):893-6. doi: 10.1042/bj2090893.
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