Allgayer H, Paumgartner G
Arzneimittelforschung. 1983;33(3):417-8.
Interactions of D-penicillamine with various antacids (aluminum hydroxide-magnesium hydroxide, AH-MH; aluminum hydroxide-calcium carbonate, AH-CC; dihydroxy sodium aluminum carbonate, DSAC; aluminum hydroxide, AH) were studied in vitro. Only a small binding to AH-MH (29.2 +/- 7.2 mumol/g antacid) and AH (13.6 +/- 4.0 mumol/g antacid) and no adsorption at all to AH-CC and DSAC were observed. Bile salts and bicarbonate as well as the pH did not influence binding. Although extrapolations from in vitro studies to in vivo conditions are hazardous, clinically relevant interactions of D-penicillamine with antacids in patients ingesting both drugs in the usual dose range simultaneously appear unlikely.
在体外研究了青霉胺与各种抗酸剂（氢氧化铝 - 氢氧化镁，AH - MH；氢氧化铝 - 碳酸钙，AH - CC；碱式碳酸二羟铝钠，DSAC；氢氧化铝，AH）的相互作用。仅观察到与AH - MH（29.2±7.2μmol/g抗酸剂）和AH（13.6±4.0μmol/g抗酸剂）有少量结合，而与AH - CC和DSAC完全没有吸附。胆汁盐、碳酸氢盐以及pH值均不影响结合。尽管从体外研究推断体内情况存在风险，但在同时服用两种药物的患者中，按照通常剂量范围，青霉胺与抗酸剂之间出现临床相关相互作用的可能性似乎不大。
