Clain J E, Malagelada J R, Chadwick V S, Hofmann A F
Gastroenterology. 1977 Sep;73(3):556-9.
The binding properties of various commercial antacids for pure conjugated bile acids in an aqueous solution or the bile acids present in human gallbladder bile were characterized. Aluminum hydroxide was a potent binding agent, similar in affinity and capacity to cholestyramine. With aluminum hydroxide, dihydroxy bile acid conjugates were bound more strongly than trihydroxy bile acid conjugates, and glycine conjugates were bound more strongly than taurine conjugates; pH had no effect per se on binding. Magnesium hydroxide and aluminum phosphate bound bile acids much more weakly. Aluminum hydroxide warrants exploration in therapeutic situations in which bile acid binding is sought.
对各种市售抗酸剂与水溶液中纯共轭胆汁酸或人胆囊胆汁中存在的胆汁酸的结合特性进行了表征。氢氧化铝是一种有效的结合剂，其亲和力和结合能力与消胆胺相似。对于氢氧化铝，二羟基胆汁酸共轭物的结合比三羟基胆汁酸共轭物更强，甘氨酸共轭物的结合比牛磺酸共轭物更强；pH本身对结合没有影响。氢氧化镁和磷酸铝对胆汁酸的结合要弱得多。在寻求胆汁酸结合的治疗情况下，氢氧化铝值得探索。
