Gikalov I, Daschner F
Arzneimittelforschung. 1983;33(5):784-6.
The bioavailability of alpha-amino-4-hydroxybenzyl-penicillin (amoxicillin) was investigated after administration of two different preparations. As test substance Sigamopen tablets were given and compared with a standard-preparation on the German market. Both preparations contained 750 mg amoxicillin. No significant differences were found in the serum concentrations, in the bioavailability or other pharmacokinetic parameters. The results obtained are in agreement with those known in the literature. Therefore, both preparations were regarded as bioequivalent.
在给予两种不同制剂后，对α-氨基-4-羟基苄基青霉素（阿莫西林）的生物利用度进行了研究。作为测试物质，给予了西格玛青霉素片，并与德国市场上的一种标准制剂进行了比较。两种制剂均含有750毫克阿莫西林。在血清浓度、生物利用度或其他药代动力学参数方面未发现显著差异。所获得的结果与文献中已知的结果一致。因此，两种制剂被视为生物等效。
