Mel'nikov V N, Shorin Iu P
Biull Eksp Biol Med. 1983 Jul;96(7):101-4.
Male Wistar rats housed under the conditions of 12L : 12D, 24 +/- 1 degree C and free access to food and water received isotonic sodium chloride solution or cortisol in doses of 2 and 4 mg/kg, respectively. Daily stress or cortisol injections in the morning or evening are the synchronizers of 11-hydroxycorticosteroid excretion rhythm. Morning stress leads to the increase of the 12-hour rhythm. On the contrary, evening stress or cortisol administration during maximal endogenous secretion of corticosteroids are associated with the elevation of circadian periodicity. Exogenic changes in the rhythmic organization of the hypothalamo-hypophyseal-adrenocortical system are followed by activation of adaptive processes involved in the normalization of the initially modified glucocorticoid rhythm.
将处于12小时光照：12小时黑暗、24±1摄氏度环境且可自由获取食物和水条件下饲养的雄性Wistar大鼠，分别给予等渗氯化钠溶液或剂量为2毫克/千克和4毫克/千克的皮质醇。每日早晨或傍晚的应激或皮质醇注射是11-羟基皮质类固醇排泄节律的同步器。早晨应激导致12小时节律增加。相反，在皮质类固醇最大内源性分泌期间的傍晚应激或皮质醇给药与昼夜周期性升高有关。下丘脑-垂体-肾上腺皮质系统节律组织的外源性变化之后是参与使最初改变的糖皮质激素节律正常化的适应性过程的激活。
