Shukla P K, Khan Z A, Lal B, Agrawal P K, Srivastava O P
Sabouraudia. 1983 Jun;21(2):137-47.
Two cases of mycotic keratitis caused by the Colletotrichum state of Glomerella cingulata and Acrophialophora fusispora are reported for the first time. Both the isolates produced experimental corneal lesions in rabbit eyes but A. fusispora was more pathogenic. The experimental infection was more severe, with both the fungi, in rabbits pretreated with cortisone as compared with untreated animals. In vitro A. fusispora was most sensitive to miconazole and tolciclate followed by clotrimazole, amphotericin B and lactones while clotrimazole exerted maximum inhibitory effect on Colletotrichum followed by miconazole, lactones, amphotericin B and arnebins. Arnebins and tolciclate were inactive respectively against A. fusispora and Colletotrichum. Of the 3 drugs tested in vivo, against A. fusispora keratitis in rabbit, amphotericin B showed better results than tolciclate and miconazole.
首次报道了由围小丛壳炭疽菌（Glomerella cingulata）的炭疽菌状态和镰刀顶孢霉（Acrophialophora fusispora）引起的两例真菌性角膜炎。两种分离株均在兔眼中产生了实验性角膜病变，但镰刀顶孢霉的致病性更强。与未治疗的动物相比，在用可的松预处理的兔子中，两种真菌引起的实验性感染都更严重。在体外，镰刀顶孢霉对咪康唑和托萘酯最敏感，其次是克霉唑、两性霉素B和内酯类，而克霉唑对炭疽菌的抑制作用最大，其次是咪康唑、内酯类、两性霉素B和阿尼芬净。阿尼芬净和托萘酯分别对镰刀顶孢霉和炭疽菌无活性。在体内对兔镰刀顶孢霉菌性角膜炎测试的3种药物中，两性霉素B的效果优于托萘酯和咪康唑。
