Mycology Division, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
J Clin Microbiol. 2011 Aug;49(8):2894-8. doi: 10.1128/JCM.00151-11. Epub 2011 Jun 8.
In recent years, the well-known plant pathogens of the Colletotrichum genus were increasingly reported to cause ophthalmic infections in humans. Among 66 species in the Colletotrichum genus, only a few are known to be pathogenic for humans. We report here five cases of ophthalmic infections due to Colletotrichum truncatum, a species never reported earlier to cause human infection. The isolates were identified by morphological characteristics and the sequencing of internal spacer regions of ribosomal DNA. The progress of lesions in those patients was slow compared to that of lesions caused by Aspergillus or Fusarium infections. The surgical management included total penetrating keratoplasty in patients with keratitis and pars plana vitrectomy in endophthalmitis. Two patients were treated additionally with intravitreal amphotericin B deoxycholate, one patient with oral itraconazole, and another patient with oral and topical fluconazole therapy. The present series therefore highlights the expanding spectrum of agents causing eye infections and the inclusion of C. truncatum as a human pathogen.
近年来，已报道越来越多的炭疽属植物病原菌会引起人类眼部感染。在炭疽属的 66 个种中，仅有少数几种被认为对人类具有致病性。我们在此报告五例由炭疽突脐孢引起的眼部感染，该种此前从未有报道会引起人类感染。通过形态特征和核糖体 DNA 内部间隔区的测序对分离株进行了鉴定。与曲霉菌或镰刀菌感染引起的病变相比，这些患者的病变进展较为缓慢。手术治疗包括角膜炎患者行全穿透性角膜移植术和眼内炎患者行玻璃体切除术。两名患者额外接受了玻璃体内两性霉素 B 脱氧胆酸盐治疗，一名患者接受了口服伊曲康唑治疗，另一名患者接受了口服和局部氟康唑治疗。本系列因此强调了引起眼部感染的病原体范围不断扩大，并将炭疽突脐孢纳入人类病原体。
