Leistenschneider W, Nagel R
Urologe A. 1983 May;22(3):144-50.
600 aspiration biopsies were performed under 6 different therapeutic conditions (estrogens, antiandrogen, Estracyt, irradiation, irradiation and estrogens, cytostatics) in patients mostly in stage T3 Nx Mo. The most important signs of regression were found in the nucleus. Compared to 102 simultaneous transrectal punch biopsies we found a diagnostic reliability for cytology of 97%. A detailed classification of the cytological signs of regression permitted a cytological grading of regression into 6 different regression grades. A surprisingly good correlation was found between grading of regression and clinical response or progression. Cytology was superior to rectal examination as a method of evaluating the effectiveness of therapies. The incidence of complications of aspiration biopsy was 1.6% and the incidence of insufficient cell material was 5.2%.
在6种不同治疗条件（雌激素、抗雄激素、依西美坦、放疗、放疗与雌激素联合、细胞抑制剂）下，对大多处于T3 Nx Mo期的患者进行了600次穿刺活检。消退的最重要迹象出现在细胞核中。与102次同时进行的经直肠穿刺活检相比，我们发现细胞学诊断可靠性为97%。对消退细胞学征象的详细分类使得能够将消退进行细胞学分级，分为6个不同的消退等级。在消退分级与临床反应或进展之间发现了惊人的良好相关性。作为评估治疗效果的方法，细胞学优于直肠检查。穿刺活检的并发症发生率为1.6%，细胞材料不足的发生率为5.2%。
