Kaneko S, Hirano T, Fukushima Y, Sato T, Nomura Y, Shinagawa S, Ogawa Y
Folia Psychiatr Neurol Jpn. 1983;37(1):25-32. doi: 10.1111/j.1440-1819.1983.tb00300.x.
To study the mechanisms of inhibitory action of antiepileptic drugs on foetal head growth, determinations were made of the growth hormone, thyrotropin and thyroid hormone levels in the sera of pregnant women, and the correlations between each hormone concentration and the foetal head circumference were studied. The thyroxine level decreased in the maternal serum and in the cord blood, and the thyrotropin level also became lower in the epileptic mother taking antiepileptic drugs. The growth hormone level in the umbilical vein sample of the epileptic mother was lower than that in the controls. The correlations between the head circumference of an infant at delivery and the decreased levels of the hormones seemed to indicate that a decrease in the thyroxine level, caused by antiepileptic drugs, produced the foetal head growth retardation.
为研究抗癫痫药物对胎儿头部生长的抑制作用机制，对孕妇血清中的生长激素、促甲状腺激素和甲状腺激素水平进行了测定，并研究了每种激素浓度与胎儿头围之间的相关性。孕妇血清和脐血中的甲状腺素水平降低，服用抗癫痫药物的癫痫母亲的促甲状腺激素水平也降低。癫痫母亲脐静脉样本中的生长激素水平低于对照组。分娩时婴儿的头围与激素水平降低之间的相关性似乎表明，抗癫痫药物导致的甲状腺素水平降低引起了胎儿头部生长迟缓。
