[Disorders in brain levels of macroergic substances during chronic stress and their correction by psychotropic agents].

The content of adenylic nucleotides (ATP, ADP and AMP) in different structures of the rat brain (cortex, limbic system, medulla oblongata) was studied in experimental chronic stress (anxiety) as was its correction with psychotropic agents--the derivatives of different chemical compounds. Stress was shown to lead to a dramatic decrease in the content of macroergic constituents in an excess-catabolic stage, largely at the expense of ATP, thereby reducing the adenylate charge. These changes were the most demonstrable in the limbic system. The medulla oblongata was little responsive to stress in this stage. Prophylactic administrations of the tranquilizers exerted a pronounced stress-protective action and made the content of macroergic constituents return to normal. GABA and nicotinic acid derivatives had the highest therapeutic effect.