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对喹啉染料迟发型超敏反应中的剂量反应关系。

Dose response relationships in delayed hypersensitivity to quinoline dyes.

作者信息

Weaver J E

出版信息

Contact Dermatitis. 1983 Jul;9(4):309-12. doi: 10.1111/j.1600-0536.1983.tb04397.x.

DOI:10.1111/j.1600-0536.1983.tb04397.x
PMID:6684531
Abstract

Repeat insult patch testing of the quinoline dyes, D & C Yellow No. 10 (Acid Yellow No. 3) and D & C Yellow No. 11 (Solvent Yellow No. 33) demonstrated that concentrations as high as 1,000 ppm of the former induced no delayed contact hypersensitivity, whereas, concentrations of 20 ppm and 10 ppm of D & C Yellow No. 11 induced delayed hypersensitivity reactions in human volunteer panelists. No definitive hypersensitivity resulted from testing with 5 ppm of this dye. 2 persons who had been demonstrated to have reacted allergically to the use of a soap bar that contained D & C Yellow No. 11 did not react to the ad libitum use of a soap bar in which this dye was replaced with D & C Yellow No. 10.

摘要

对喹啉染料(D&C黄10号,即酸性黄3号;以及D&C黄11号,即溶剂黄33号)进行重复刺激斑贴试验表明,高达1000 ppm的前者浓度不会诱发迟发型接触性超敏反应,而20 ppm和10 ppm浓度的D&C黄11号会在人类志愿者小组中诱发迟发型超敏反应。用5 ppm的这种染料进行测试未产生明确的超敏反应。2名已被证明对含有D&C黄11号的肥皂块使用产生过敏反应的人,在随意使用将该染料替换为D&C黄10号的肥皂块时没有反应。

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