Van Daal W A, Goslings B M, Hermans J, Ruiter D J, Sepmeyer C F, Vink M, Van Vloten W A, Thomas P
Eur J Cancer Clin Oncol. 1983 Aug;19(8):1081-6. doi: 10.1016/0277-5379(83)90031-7.
Six hundred and five persons, randomly selected from a cohort of 2400 patients who had been irradiated 16-46 yr previously for benign diseases in the head and neck region, were traced, recalled and examined for radiation-associated tumours. Three hundred and sixty-seven patients were alive, 179 had died and 66 had emigrated. Two hundred and fifty-seven patients were clinically examined, 87 refused or were not able to participate and 16 could not be contacted. Eighteen of the clinically examined patients had been or were being treated for 20 skin carcinomas with a mean latency of 37 yr. In this group only 7 carcinomas of the thyroid gland were observed, with a mean latency of 38 yr. Eleven carcinomas of the skin and 3 of the thyroid gland were reported in the group which was examined by means of questionnaires. The observed number of carcinomas of the skin is higher than expected according to the dose-effect relationship of UNSCEAR, whereas the number of carcinomas of the thyroid gland is lower. It is concluded that there might be less difference in susceptibility for the induction of tumours by ionizing radiation between the skin and the thyroid gland than is commonly assumed.
从2400名16至46年前因头颈部良性疾病接受过放射治疗的患者队列中随机选取605人，对其进行追踪、召回并检查是否患有与辐射相关的肿瘤。367名患者存活，179名患者死亡，66名患者移民。257名患者接受了临床检查，87名患者拒绝或无法参与，16名患者无法取得联系。18名接受临床检查的患者曾接受或正在接受20例皮肤癌治疗，平均潜伏期为37年。在该组中，仅观察到7例甲状腺癌，平均潜伏期为38年。通过问卷调查方式检查的组中报告了11例皮肤癌和3例甲状腺癌。根据联合国原子辐射效应科学委员会（UNSCEAR）的剂量效应关系，观察到的皮肤癌数量高于预期，而甲状腺癌数量则较低。得出结论认为，皮肤和甲状腺对电离辐射诱发肿瘤的易感性差异可能比通常认为的要小。
