van der Laan B F, Baris G, Gregor R T, Hilgers F J, Balm A J
Department of Otolaryngology, The Netherlands Cancer Institute, (Antoni van Leeuwenhoekhuis), Amsterdam.
J Laryngol Otol. 1995 Apr;109(4):346-9. doi: 10.1017/s0022215100130117.
In order to study the induction of malignancy in normal tissues due to ionizing radiation, we reviewed the files of 2500 patients with a tumour of the head and neck treated at the Netherlands Cancer Institute (Antoni van Leeuwenhoek Ziekenhuis), Amsterdam, from 1977 to 1993. We then checked whether or not these patients had been previously irradiated. Patients with a thyroid carcinoma or skin cancer were excluded from the study, since it is generally known that previous irradiation is a risk factor in these tumours. Eighteen patients were found to have a malignancy within a previously irradiated area (0.70 per cent). The mean interval between radiation and diagnosis of the head and neck tumour was 36.5 years. There were five soft tissue sarcomas, nine squamous cell carcinomas and four salivary gland tumours. Fourteen patients were operated upon whereas four received palliative treatment only. The median survival of the total group was 3.5 years. Particularly, in young patients because of the better cancer therapy and prolonged survival one must be aware of the increased risk of radiation-induced tumours.
为了研究电离辐射导致正常组织发生恶性肿瘤的情况，我们查阅了1977年至1993年期间在阿姆斯特丹荷兰癌症研究所（安东尼·范·列文虎克医院）接受治疗的2500例头颈部肿瘤患者的病历。然后我们核查这些患者之前是否接受过放疗。甲状腺癌或皮肤癌患者被排除在研究之外，因为众所周知，既往放疗是这些肿瘤的一个风险因素。我们发现有18例患者在先前接受过放疗的区域发生了恶性肿瘤（0.70%）。放疗与头颈部肿瘤诊断之间的平均间隔时间为36.5年。其中有5例软组织肉瘤、9例鳞状细胞癌和4例唾液腺肿瘤。14例患者接受了手术治疗，而4例仅接受了姑息治疗。整个组的中位生存期为3.5年。特别是对于年轻患者，由于癌症治疗效果更好且生存期延长，必须意识到辐射诱发肿瘤的风险增加。
