Lichardus B, Szabóová A, Földes O, Ponec J, Horký K, Srámková J
Exp Clin Endocrinol. 1983 Jul;82(1):107-10. doi: 10.1055/s-0029-1210264.
Experimental hyperadiuretism in pregnant rats was induced by applying them daily throughout the pregnancy a synthetic analogue of vasopressin--dDAVP (1-deamino-8-D-arginine vasopressin). It brought about a moderate alteration in the ability to produce hypertonic urine in their offsprings. The osmoregulatory function in the offsprings in the course of fetal development could have been suppressed either by a direct or an indirect effect of dDAVP i.e. by the hypotonicity of mothers' internal environment. There is by now some evidence based on the simultaneous determination of urinary vasopressin and osmolality that the impairment of the osmoregulatory function may be, at least partly, on the renal level.
在整个孕期每天给怀孕大鼠注射血管加压素的合成类似物——去氨加压素（1-脱氨基-8-D-精氨酸血管加压素），诱导其产生实验性高利尿作用。这使其后代产生高渗尿的能力发生了适度改变。在胎儿发育过程中，去氨加压素的直接或间接作用，即母亲内环境的低渗性，可能抑制了后代的渗透调节功能。目前有一些基于同时测定尿血管加压素和渗透压的证据表明，渗透调节功能的损害可能至少部分发生在肾脏水平。
