Zofková I, Neradilová M, Stárka L, Kimlová I, Simecková A
Exp Clin Endocrinol. 1983 Jul;82(1):91-6. doi: 10.1055/s-0029-1210260.
The authors investigated in 19 healthy women changes in the plasma levels of cortisol and growth hormone during acute hypercalcaemia induced by a load of 8.9 mg Ca2+/kg body weight, administered as intravenous infusion and the effect of hypercalcaemia on the adrenocortical and somatotrophic secretory reserve assessed by the test with insulin hypoglycaemia. Hypercalcaemia causes a rise of the basal cortisol plasma level starting at the 90th minute from the onset of the infusion when the calcium level reaches values of 2.99 mmol/l. The adrenocortical secretory reserve is, however, significantly reduced by hypercalcaemia. Hypercalcaemia does not affect growth levels nor the somatotrophic secretory reserve.
作者对19名健康女性进行了研究，通过静脉输注8.9mg Ca2+/kg体重负荷诱导急性高钙血症，观察皮质醇和生长激素的血浆水平变化，以及通过胰岛素低血糖试验评估高钙血症对肾上腺皮质和生长激素分泌储备的影响。高钙血症会导致从输注开始第90分钟起基础皮质醇血浆水平升高，此时钙水平达到2.99mmol/l。然而，高钙血症会显著降低肾上腺皮质分泌储备。高钙血症不影响生长激素水平及生长激素分泌储备。
