与线性生长相关的皮质醇和生长激素分泌：不同治疗方案下的斯蒂尔病患者
Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens.
作者信息
Sturge R A, Beardwell C, Hartog M, Wright D, Ansell B M
出版信息
Br Med J. 1970 Sep 5;3(5722):547-51. doi: 10.1136/bmj.3.5722.547.
Abstract
Linear growth was studied in 20 children suffering from Still's disease on various treatment regimens, and their ability to secrete growth hormone and cortisol was investigated. Growth recovered on reducing daily corticosteroid therapy or on changing to an alternative regimen. Retardation of growth was not due to an absolute inability to secrete growth hormone. Basal plasma cortisol levels and the plasma cortisol response to hypoglycaemia were reduced in patients on daily steroid therapy, but patients on alternate-day prednisone did not differ significantly in this respect from those on non-steroid regimens. Those on alternate-day corticotrophin showed preservation of the circadian rhythm but a subnormal response to hypoglycaemia.
摘要
对20名患有斯蒂尔病且接受各种治疗方案的儿童的线性生长情况进行了研究，并对他们分泌生长激素和皮质醇的能力进行了调查。在减少每日皮质类固醇治疗或改用替代方案后，生长情况有所恢复。生长迟缓并非由于绝对无法分泌生长激素。每日接受类固醇治疗的患者，其基础血浆皮质醇水平以及血浆皮质醇对低血糖的反应均降低，但隔日服用泼尼松的患者在这方面与接受非类固醇治疗方案的患者并无显著差异。隔日接受促肾上腺皮质激素治疗的患者，其昼夜节律得以保留，但对低血糖的反应低于正常水平。
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