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1
Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens.与线性生长相关的皮质醇和生长激素分泌：不同治疗方案下的斯蒂尔病患者
Br Med J. 1970 Sep 5;3(5722):547-51. doi: 10.1136/bmj.3.5722.547.
2
Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth.促肾上腺皮质激素疗法治疗青少年慢性多关节炎（斯蒂尔病）及其对生长的影响。
Arch Dis Child. 1971 Oct;46(249):584-93. doi: 10.1136/adc.46.249.584.
3
Levels of growth hormone, insulin-like growth factor-I (IGF-I) and -II, IGF-binding protein-1 and -3, and cortisol in prednisone-treated children with growth retardation after renal transplantation.肾移植后生长迟缓的泼尼松治疗儿童的生长激素、胰岛素样生长因子-I（IGF-I）和-II、IGF结合蛋白-1和-3以及皮质醇水平。
J Clin Endocrinol Metab. 1993 Oct;77(4):932-8. doi: 10.1210/jcem.77.4.7691864.
4
Intermittent steroid therapy. Its effect on hypothalamic-pituitary-adrenal function and the response of plasma growth hormone and insulin to stimulation.间歇性类固醇疗法。其对下丘脑 - 垂体 - 肾上腺功能的影响以及血浆生长激素和胰岛素对刺激的反应。
N Engl J Med. 1968 Aug 8;279(6):273-8. doi: 10.1056/NEJM196808082790601.
5
Daily fluctuations in the plasma cortisol level of children with rheumatoid arthritis before and after treatment with tetracosactrin ('Cortrosyn Depot') and corticosteroid hormones.类风湿性关节炎患儿在使用二十四肽促皮质素（“长效考的松”）和皮质类固醇激素治疗前后血浆皮质醇水平的每日波动情况。
Curr Med Res Opin. 1977;4(7):477-84. doi: 10.1185/03007997709109336.
6
The plasma cortisol and corticotropin response to hypoglycemia following adrenal steroid and ACTH administration.肾上腺类固醇和促肾上腺皮质激素给药后血浆皮质醇和促肾上腺皮质激素对低血糖的反应。
J Clin Endocrinol Metab. 1975 Jul;41(1):1-6. doi: 10.1210/jcem-41-1-1.
7
Ghrelin does not regulate the GH response to insulin-induced hypoglycaemia in children but could be involved in the regulation of cortisol secretion.胃饥饿素并不调节儿童生长激素对胰岛素诱导的低血糖的反应，但可能参与皮质醇分泌的调节。
Clin Endocrinol (Oxf). 2007 Jan;66(1):143-7. doi: 10.1111/j.1365-2265.2006.02701.x.
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Growth in Still's disease.斯蒂尔病的病情进展
Lancet. 1971 Nov 27;2(7735):1188-9.
9
Plasma corticotropin, cortisol and growth hormone responses to hypoglycemia in the morning and in the evening.早晨和晚上血浆促肾上腺皮质激素、皮质醇及生长激素对低血糖的反应。
J Clin Endocrinol Metab. 1972 May;34(5):895-8. doi: 10.1210/jcem-34-5-895.
10
The effect of administered corticosteroids on the growth of children.施用皮质类固醇对儿童生长的影响。
Postgrad Med J. 1976 Oct;52(612):625-30. doi: 10.1136/pgmj.52.612.625.

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1
Sexual maturation in Moroccan patients with juvenile idiopathic arthritis.摩洛哥青少年特发性关节炎患者的性成熟情况
Rheumatol Int. 2014 May;34(5):665-8. doi: 10.1007/s00296-013-2737-9. Epub 2013 Apr 4.
2
Low cortisol levels in active juvenile idiopathic arthritis.活动期幼年特发性关节炎患者皮质醇水平降低。
Clin Rheumatol. 2010 Mar;29(3):309-14. doi: 10.1007/s10067-009-1326-5. Epub 2009 Dec 15.
3
Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.白细胞介素6通过降低胰岛素样生长因子-I导致转基因小鼠生长受损。慢性炎症儿童生长发育迟缓的一种模型。
J Clin Invest. 1997 Feb 15;99(4):643-50. doi: 10.1172/JCI119207.
4
Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration.不同类固醇给药治疗方案下儿童肾病患者的血清25（OH）D和24,25（OH）₂水平
Eur J Pediatr. 1982 Mar;138(2):162-5. doi: 10.1007/BF00441145.
5
Effect of different corticosteroid regimens on hypothalamic-pituitary-adrenal axis and growth in juvenile chronic arthritis.不同皮质类固醇治疗方案对青少年慢性关节炎下丘脑-垂体-肾上腺轴及生长发育的影响
J R Soc Med. 1983 Jun;76(6):452-7. doi: 10.1177/014107688307600604.
6
Growth hormone studies in patients with rheumatoid arthritis with or without glucocorticoid therapy.类风湿关节炎患者使用或不使用糖皮质激素治疗时的生长激素研究。
Z Kinderheilkd. 1974;118(1):53-62. doi: 10.1007/BF00506053.
7
Growth and skeletal maturation in congenital adrenal hyperplasia. Review of 20 cases.先天性肾上腺皮质增生症的生长与骨骼成熟：20例病例回顾
Arch Dis Child. 1974 Jan;49(1):4-7. doi: 10.1136/adc.49.1.4.
8
Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth.促肾上腺皮质激素疗法治疗青少年慢性多关节炎（斯蒂尔病）及其对生长的影响。
Arch Dis Child. 1971 Oct;46(249):584-93. doi: 10.1136/adc.46.249.584.
9
Growth and endocrine function in steroid sensitive nephrotic syndrome.类固醇敏感型肾病综合征的生长与内分泌功能
Arch Dis Child. 1988 May;63(5):484-90. doi: 10.1136/adc.63.5.484.
10
Insulin-like growth factor and growth hormone secretion in juvenile chronic arthritis.青少年慢性关节炎中的胰岛素样生长因子与生长激素分泌
Ann Rheum Dis. 1991 Sep;50(9):602-6. doi: 10.1136/ard.50.9.602.

本文引用的文献

1
THE REGULATION OF GROWTH HORMONE SECRETION.生长激素分泌的调节
Recent Prog Horm Res. 1965;21:241-83.
2
DIURNAL VARIATION IN SUPPRESSION OF ADRENAL FUNCTION BY GLUCOCORTICOIDS.糖皮质激素对肾上腺功能抑制的昼夜变化
J Clin Endocrinol Metab. 1965 Mar;25:343-9. doi: 10.1210/jcem-25-3-343.
3
HUMAN GROWTH HORMONE. CLINICAL MEASUREMENT, RESPONSE TO HYPOGLYCEMIA AND SUPPRESSION BY CORTICOSTEROIDS.人类生长激素。临床测量、对低血糖的反应及皮质类固醇的抑制作用
N Engl J Med. 1964 Dec 31;271:1375-81. doi: 10.1056/NEJM196412312712701.
4
EFFECT OF CORTICOSTEROIDS ON SERUM GROWTH HORMONE.皮质类固醇对血清生长激素的影响。
Lancet. 1964 Aug 22;2(7356):376-8. doi: 10.1016/s0140-6736(64)90389-7.
5
STUDIES ON AN INTERMITTENT CORTICOSTEROID DOSAGE REGIMEN.间歇性皮质类固醇给药方案的研究
N Engl J Med. 1963 Sep 19;269:591-6. doi: 10.1056/NEJM196309192691201.
6
Secretion of human growth hormone: physiologic and experimental modification.人生长激素的分泌：生理及实验性调节
Metabolism. 1963 Jul;12:577-9.
7
Growth in Still's disease.斯蒂尔病中的生长
Ann Rheum Dis. 1956 Dec;15(4):295-319. doi: 10.1136/ard.15.4.295.
8
Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children.长期使用可的松治疗对儿童身高增长、骨骼成熟和代谢状况的影响。
N Engl J Med. 1956 Apr 5;254(14):636-41. doi: 10.1056/NEJM195604052541402.
9
Studies of growth hormone secretion in children: normal, hypopituitary and constitutionally delayed.儿童生长激素分泌的研究：正常、垂体功能减退和体质性生长延迟。
J Clin Endocrinol Metab. 1967 Oct;27(10):1409-17. doi: 10.1210/jcem-27-10-1409.
10
Growth hormone secretion provoked by insulin-induced hypoglycaemia in children of short stature.胰岛素诱导的低血糖对身材矮小儿童生长激素分泌的影响
Arch Dis Child. 1967 Jun;42(223):232-8. doi: 10.1136/adc.42.223.232.

与线性生长相关的皮质醇和生长激素分泌：不同治疗方案下的斯蒂尔病患者

Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens.

作者信息

Sturge R A, Beardwell C, Hartog M, Wright D, Ansell B M

出版信息

Br Med J. 1970 Sep 5;3(5722):547-51. doi: 10.1136/bmj.3.5722.547.

DOI:10.1136/bmj.3.5722.547
PMID:4318282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1701579/
Abstract

Linear growth was studied in 20 children suffering from Still's disease on various treatment regimens, and their ability to secrete growth hormone and cortisol was investigated. Growth recovered on reducing daily corticosteroid therapy or on changing to an alternative regimen. Retardation of growth was not due to an absolute inability to secrete growth hormone. Basal plasma cortisol levels and the plasma cortisol response to hypoglycaemia were reduced in patients on daily steroid therapy, but patients on alternate-day prednisone did not differ significantly in this respect from those on non-steroid regimens. Those on alternate-day corticotrophin showed preservation of the circadian rhythm but a subnormal response to hypoglycaemia.

摘要

对20名患有斯蒂尔病且接受各种治疗方案的儿童的线性生长情况进行了研究，并对他们分泌生长激素和皮质醇的能力进行了调查。在减少每日皮质类固醇治疗或改用替代方案后，生长情况有所恢复。生长迟缓并非由于绝对无法分泌生长激素。每日接受类固醇治疗的患者，其基础血浆皮质醇水平以及血浆皮质醇对低血糖的反应均降低，但隔日服用泼尼松的患者在这方面与接受非类固醇治疗方案的患者并无显著差异。隔日接受促肾上腺皮质激素治疗的患者，其昼夜节律得以保留，但对低血糖的反应低于正常水平。