Leake R D, Waters C B, Rubin R T, Buster J E, Fisher D A
Obstet Gynecol. 1983 Nov;62(5):565-8.
Plasma levels of oxytocin and prolactin were measured before and during 12 minutes of breast pump stimulation in five healthy, lactating, amenorrheic women on three occasions: ten to 90 days post partum, 90 to 180 days post partum, and 180 days to one year post partum. Baseline mean (+/- SEM) plasma oxytocin levels were similar in the three study periods. Mean stimulated plasma oxytocin levels increased in the three study periods (each P less than .001; mean baseline versus stimulated). Stimulated plasma oxytocin values were significantly greater at ten to 90 than at 90 to 180 days (P less than .05; analysis of variance). Baseline serum prolactin levels were 61 +/- 9.5, 36 +/- 8.6, and 33 +/- 10.8 ng/ml, respectively (not significant; one-way analysis of variance). Mean stimulated prolactin levels were 71 +/- 8.1, 43 +/- 4.5, and 43 +/- 2.8 ng/ml, respectively (not significant). Thus, the oxytocin secretory reflex continues in long-term lactation for the first year post partum. In addition, breast stimulation in long-term lactating women continues to produce a slight increase in serum prolactin levels.
在五名健康、哺乳期且闭经的女性产后10至90天、90至180天以及180天至1年这三个时间段，分别在使用吸奶器刺激12分钟之前和期间测量了她们血浆中的催产素和催乳素水平。三个研究阶段的基线平均（±标准误）血浆催产素水平相似。在三个研究阶段，刺激后的血浆催产素平均水平均有所升高（每个P值均小于0.001；基线平均值与刺激后平均值相比）。产后10至90天刺激后的血浆催产素值显著高于90至180天（P值小于0.05；方差分析）。基线血清催乳素水平分别为61±9.5、36±8.6和33±10.8 ng/ml（无显著性差异；单向方差分析）。刺激后的催乳素平均水平分别为71±8.1、43±4.5和43±2.8 ng/ml（无显著性差异）。因此，产后第一年的长期哺乳期内催产素分泌反射持续存在。此外，长期哺乳女性的乳房刺激仍会使血清催乳素水平略有升高。
