Zidar B L, Pugh R P, Schiffer L M, Raju R N, Vaidya K A, Bloom R L, Horne D, Baker L H
Cancer. 1983 Nov 15;52(10):1788-91. doi: 10.1002/1097-0142(19831115)52:10<1788::aid-cncr2820521005>3.0.co;2-#.
Six patients with unresectable malignant mesothelioma were treated with chemotherapy consisting of doxorubicin and cisplatin every 3 weeks. One patient with paratesticular mesothelioma metastatic to lungs entered complete remission for 8 months; his disease has relapsed but he is alive 32 months after initiation of chemotherapy. One patient with peritoneal mesothelioma achieved partial response for 12 months. Two patients with pleural mesothelioma achieved a partial response of 5- and 6-month durations, respectively. Two patients with pleural mesothelioma failed to respond to this regimen. Thus, four of six patients responded to doxorubicin-cisplatin chemotherapy. These preliminary results merit further study and confirmation; future investigations of cisplatin alone are necessary to better define the role of this agent in mesothelioma.
6例无法切除的恶性间皮瘤患者接受了每3周一次的阿霉素和顺铂联合化疗。1例睾丸旁间皮瘤转移至肺部的患者完全缓解8个月；其疾病复发，但在化疗开始后32个月仍存活。1例腹膜间皮瘤患者部分缓解12个月。2例胸膜间皮瘤患者分别部分缓解5个月和6个月。2例胸膜间皮瘤患者对该方案无反应。因此，6例患者中有4例对阿霉素-顺铂化疗有反应。这些初步结果值得进一步研究和证实；未来单独对顺铂进行研究对于更好地确定该药物在间皮瘤中的作用是必要的。
