Wile A G, Nahabedian M Y, Mason G R
J Surg Oncol. 1983 Oct;24(2):119-23. doi: 10.1002/jso.2930240211.
The purpose of this study was to investigate the interaction of heat and chemotherapy in experimental whole body hyperthermia (WBH). A vascular technique of extracorporeal perfusion was employed to rapidly elevate body temperature in rabbits carrying the transplantable VX-2 carcinoma. Hyperthermia (greater than 41 degrees C) was achieved in a mean time of 28 minutes. Tumor-bearing rabbits receiving WBH alone exhibited poor mean survival (14 days) relative to untreated tumor-bearing animals (32 days) and the group receiving IV Cis-platinum alone (50 days) (NS, p less than .05 respectively). WBH with Cis-platinum was intermediate in terms of mean survival (30 days, NS) between the WBH alone and Cis-platinum alone groups. In this experimental model we have determined WBH to be a detrimental form of cancer therapy. Its action appears to enhance tumor proliferation, resulting in rapid animal demise. In light of these findings a reevaluation of clinical WBH may be warranted.
本研究的目的是调查实验性全身热疗（WBH）中热与化疗的相互作用。采用体外灌注的血管技术迅速提高携带可移植VX-2癌的兔子的体温。平均28分钟内实现了热疗（高于41摄氏度）。相对于未治疗的荷瘤动物（32天）和单独接受静脉注射顺铂的组（50天），单独接受WBH的荷瘤兔子平均生存期较差（14天）（无统计学意义，p分别小于0.05）。WBH联合顺铂的平均生存期（30天，无统计学意义）介于单独WBH组和顺铂单独组之间。在这个实验模型中，我们已确定WBH是一种有害的癌症治疗形式。其作用似乎会增强肿瘤增殖，导致动物迅速死亡。鉴于这些发现，可能有必要对临床WBH进行重新评估。
