Oei T P
Pharmacol Biochem Behav. 1983 Sep;19(3):453-5. doi: 10.1016/0091-3057(83)90119-3.
The present experiments attempted to study the effects of food deprivation and body weight reduction on cocaine self-administration. Rats whose body weight was reduced to 80% free feeding weight (FFW) with 23 hours' food deprivation increased cocaine intake by 30-fold compared to 100% FFW animals. The results demonstrated that, in rats, body weight reduction and the state of food deprivation interact to further enhance self-administration of cocaine. From the practical point of view, the results suggest that there may be an increased risk of drug dependence with patients taking stimulants to control body weight.
本实验试图研究食物剥夺和体重减轻对可卡因自我给药的影响。通过23小时食物剥夺使体重降至自由进食体重（FFW）80%的大鼠，与100%FFW的动物相比，可卡因摄入量增加了30倍。结果表明，在大鼠中，体重减轻和食物剥夺状态相互作用，进一步增强了可卡因的自我给药。从实际角度来看，结果表明服用兴奋剂来控制体重的患者可能有更高的药物依赖风险。
