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[用超氧化物歧化酶治疗膀胱单纯性溃疡和放射性膀胱炎溃疡]

[Treatment of ulcus simplex of the bladder and ulcerating radiogenic cystitis with superoxide dismutase].

作者信息

Reuss K, Carl P

出版信息

Urologe A. 1983 Sep;22(5):290-3.

PMID:6685380
Abstract

Treatment of ulcus simplex vesicae and post irradiation ulcer of the bladder with superoxide dismutase (SOD) is reported. Its antiinflammatory effect depends on the elimination of cytotoxic superoxide radicals from tissue. SOD is injected into the bladderwall during general anesthesia using a transurethral access. We treated 8 women, 4 of them suffering from ulcus simplex vesicae and 4 of them suffering from post irradiation ulcer of the bladder. In most cases we saw prompt relief from subjective complaints and healing of the ulceration. When necessary the injection was repeated once or twice in a fortnight. We did not see any side effects.

摘要

报道了用超氧化物歧化酶(SOD)治疗膀胱单纯性溃疡和膀胱放疗后溃疡。其抗炎作用取决于从组织中清除具有细胞毒性的超氧自由基。在全身麻醉下通过经尿道途径将SOD注入膀胱壁。我们治疗了8名女性,其中4名患有膀胱单纯性溃疡,4名患有膀胱放疗后溃疡。在大多数情况下,我们看到主观症状迅速缓解,溃疡愈合。必要时,每隔两周重复注射一次或两次。我们未观察到任何副作用。

相似文献

1
[Treatment of ulcus simplex of the bladder and ulcerating radiogenic cystitis with superoxide dismutase].[用超氧化物歧化酶治疗膀胱单纯性溃疡和放射性膀胱炎溃疡]
Urologe A. 1983 Sep;22(5):290-3.
2
[Therapeutic possibilities in ulcus simplex vesicae].[膀胱单纯性溃疡的治疗可能性]
Z Urol Nephrol. 1978 Apr;71(4):251-5.
3
Prevention of radioinduced cystitis by orgotein: a randomized study.
Anticancer Res. 1996 Jul-Aug;16(4A):2025-8.
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[TREATMENT OF THE ULCUS SIMPLEX VESICAE URINARIAE (HUNNER'S ULCER) WITH HEPARIN].[肝素治疗膀胱单纯性溃疡(亨纳氏溃疡)]
Z Urol. 1964 Dec;57:895-8.
5
Irradiation ulcer of the urinary bladder.膀胱放射性溃疡
Obstet Gynecol. 1967 Jul;30(1):23-7.
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[Cytologic studies in the diagnosis and evaluation of the effectiveness of treatment of radiation injuries of the urinary bladder].[膀胱放射性损伤诊断及治疗效果评估中的细胞学研究]
Vopr Onkol. 1970;16(2):44-50.
7
[Clinical experiences with orgotein in urologic diseases].[奥古蛋白治疗泌尿系统疾病的临床经验]
Eur J Rheumatol Inflamm. 1981;4(2):260-3.
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Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo-controlled study in patients with bladder tumours.有机金属蛋白酶(超氧化物歧化酶):一种减轻辐射副作用的药物。一项针对膀胱肿瘤患者的双盲、安慰剂对照研究。
Urol Res. 1978;6(4):255-7. doi: 10.1007/BF00262630.
9
[Radiogenic cystitis; endoscopic diagnosis, classification and therapy].[放射性膀胱炎;内镜诊断、分类及治疗]
Fortschr Med. 1978 Jan 19;96(3):136-8.
10
[Mechanism of the therapeutic effect of exogenous superoxide dismutase: findings and prospects].[外源性超氧化物歧化酶治疗作用机制:研究结果与展望]
Eur J Rheumatol Inflamm. 1981;4(2):183-200.

引用本文的文献

1
Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis.针对盆腔接受根治性放疗患者的晚期放射性膀胱炎的非手术干预措施。
Cochrane Database Syst Rev. 2002;2002(3):CD001773. doi: 10.1002/14651858.CD001773.
2
Superoxide dismutase for therapeutic use: clinical experience, dead ends and hopes.用于治疗的超氧化物歧化酶:临床经验、困境与希望
Mol Cell Biochem. 1988 Dec;84(2):123-31. doi: 10.1007/BF00421046.