Flohé L, Loschen G
Eur J Rheumatol Inflamm. 1981;4(2):183-200.
The hazards arising from oxygen radicals and the enzymatic function of superoxide dismutase (SOD) is discussed with regard to established and potential therapeutic effects of the injected enzyme. A monistic interpretation of the therapeutic effect of SOD in inflammatory diseases considers .02- production as a pathogenetic principle and the enzymatic elimination of the harmful radical by exogenous SOD as the counterbalancing mechanism. This hypothesis is elaborated upon taking into account the sites of endogenous .02- production, established .02-dependent types of tissue damage and availability of injected SOD. It is concluded that clinical conditions associated with .02- release from inflammatory cells will benefit from SOD injections, if relevant tissue levels are provided.
就注射用超氧化物歧化酶（SOD）既有的和潜在的治疗效果，讨论了氧自由基产生的危害以及SOD的酶功能。对SOD在炎症性疾病中的治疗作用的一元论解释认为，.02-的产生是一种发病机制，而外源性SOD对有害自由基的酶促清除是一种平衡机制。考虑到内源性.02-产生的部位、已确定的.02-依赖性组织损伤类型以及注射用SOD的可用性，对这一假设进行了详细阐述。得出的结论是，如果能提供相关的组织水平，与炎症细胞释放.02-相关的临床病症将从SOD注射中受益。
